Genetic and Molecular Testing

Commercial Reimbursement Policy

Origination Date: 05/2025

Last Review Date: 11/2025

Description

This policy addresses genetic and molecular testing services and applies to codes billed from the following sections in the CPT/HCPCS Manual:

  • Molecular Pathology
  • Genomic Sequencing Procedures and Other Molecular Multianalyte Assays (GSP)
  • Multianalyte Assays with Algorithmic Analyses (MAAA)
  • Proprietary Lab Analysis (PLA)

Policy

Blue Cross Blue Shield North Carolina (Blue Cross NC) allows reimbursement for genetic testing, in accordance with the guidelines outlined below.

Reimbursement Guidelines

All providers billing for genetic and molecular testing services must bill according to the following requirements (or services may be denied):

  • Bill for the test performed as indicated on the test requisition form and delivered on the test result

  • Include ordering provider information on all claim transactions or the services may be denied

  • Coding must be consistent with AMA coding guidelines:

    • Codes are determined based on the attributes of the testing performed, not based on the clinical indication of the member
    • If a test qualifies for panel code(s), the panel code(s) must be used. Per the NCCI Manual, Chapter 10, Section F-8, if one laboratory procedure evaluates multiple genes using a next generation sequencing procedure, the laboratory shall report only one unit of service of one genomic sequencing procedure
    • For molecular pathology procedures, if a panel code is not appropriate or is not specified in code ranges 81161 and 81200-81383, providers may be eligible for reimbursement by reporting one unit of the unlisted molecular pathology procedure code 81479
    • Only one unit of the miscellaneous, unlisted molecular pathology procedure code 81479 may be billed per test.e billed per test.

Billing and Coding

Applicable codes are for reference only and may not be all inclusive.  For further information on reimbursement guidelines, please see the Blue Cross NC web site at www.bcbsnc.com.

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Related Coding Description
81479 Unlisted Molecular Pathology Procedure

Bundling Guidelines

NCCI Editing

Once in a Lifetime

Pricing and Adjudication Principles

References

American Medical Association, Current Procedural Terminology (CPT®) and associated publications and services

CMS NCCI Policy Manual
https://www.cms.gov/medicare/coding-billing/national-correct-coding-initiative-ncci-edits/medicare-ncci-policy-manual

History

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Date Revision
8/01/2025 New policy developed.   Notification on 6/01/2025 for effective date 8/01/2025.  (ss)
2/1/2026 Added update for unlisted molecular pathology procedures billing. RPOC approved.  Notification on 12/01/2025 for effective date 2/01/2026.  (ss)

Application

These reimbursement requirements apply to all commercial, Administrative Services Only (ASO), and Blue Card Inter-Plan Program Host members (other Plans members who seek care from the NC service area).

This policy relates only to the services or supplies described herein. Please refer to the Member's Benefit Booklet for availability of benefits. Member's benefits may vary according to benefit design; therefore, member benefit language should be reviewed before applying the terms of this policy.